FLAME
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ULTRASOUND NEUROMODULATION RESEARCH

FLAME · Feasibility, Localization, Analysis, Modeling & Experimentation

Don’t fund the same experiment twice.
Someone’s already measuring it.

FLAME brings ultrasound neuromodulation teams together to share compatible experiments—even when their devices target different brain regions. Split the cost and receive organized, quality-reviewed data.

Our own computational model, DTUSN, adds a planned layer of validation for suitable projects: comparing measurements with simulated neuronal responses to flag discrepancies for review.

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DTUSN model · Presented at MIT IEEE URTC 2025
YOUR PROJECT DELIVERABLES

What you get

01
A share of the costPay for access to an agreed shared study instead of duplicating the full experiment.
02
Organized, quality-reviewed dataRaw files, methods, calibration records, and documented checks in one package.
03
Analysis already doneA clear results report, uncertainties, and next steps—without assembling it yourself.
04
An additional DTUSN checkFor suitable data, a model comparison flags discrepancies for further review.

Shared and customer-specific work are itemized in your quote.

View a sample outline

THE SHARED-STUDY ADVANTAGE

Different products.
Overlapping research needs.

Different brain targets can still require common acoustic measurements. Pooling those measurements is like buying experiments in bulk.

Team A · Motor cortex deviceTeam B · Prefrontal cortex deviceShared need · Acoustic characterization
Shared measurement studyShared setup, equipment, and measurement costs
Data each team can useOrganized files + quality checks + analysis

Illustrative example, not an active study. Different brain targets still require target-specific evidence. Only measurements with compatible methods, data rights, and quality requirements are shared. Savings depend on participation and scope; unique or confidential work can be quoted separately.

THE DTUSN MODEL

DTUSN adds another
layer of review.

Presented at MIT IEEE URTC 2025

Our DTUSN (Digital Twin for Ultrasound Stimulation of Neurons) research model simulates how ultrasound can affect neuronal activity by combining acoustic fields with a biophysical neuron model.

For suitable projects, FLAME plans to compare measured results with DTUSN simulations. You receive the comparison, its assumptions, and any discrepancies that need review.

DTUSN is a research prototype. Model agreement does not establish biological validity or safety.

Read the research paper
01

Simulate

Model acoustic input and neuronal response.

02

Compare

Examine where observations and model outputs agree or differ.

03

Report

Document assumptions, discrepancies, and limitations.

Technical details & limitations +

The paper combines k-Wave pressure fields, confocal-derived morphology, and a multicompartment NEURON model. Calibration is limited, pressure-to-voltage coupling is simplified, and the CNN prediction layer remains under development.

The separate runnable Hodgkin–Huxley simulator is illustrative, not the complete paper pipeline. Each comparison must identify the model version and calibration, and distinguish simulated outputs from measured data.

What is ultrasound neuromodulation? +

It is the study of how sound waves influence neural activity through interactions with neuronal membranes and ion channels. Researchers investigate how responses change with acoustic parameters. Read the ITRUSST research resources ↗

How it works

Tell us what data you need. We look for a shared scope and handle coordination and review.

01

Match data needs

We identify which measurements can serve you and other customers.

02

Agree your share

Review deliverables, data rights, and your portion of the study cost before paying.

03

Run & review

We coordinate qualified providers and the agreed measurement, calibration, and data-quality checks.

04

Get a usable package

Receive organized data and completed analysis, plus a DTUSN comparison where suitable.

Your quote separates shared study costs, FLAME’s coordination and review fee, and any work specific to your project. Required contracts and approvals come before execution.

RESEARCH OPTIONS

Choose the work you need.

Use existing evidence, join a compatible shared study, or scope specialist work. Choose the data depth and equipment your question needs.

For independent researchers and students. Start with data review or planning.

Existing evidence

Explore

Review existing evidence before funding an experiment.

Lower-cost scope
  • Evidence review & data requirements
  • Feasibility & evidence-gap review
  • Study recommendation & planning budget
New measurements

Investigate

Pool compatible bench or phantom measurements with other customers.

Project-based quote
  • Shared study scope & cost allocation
  • Agreed measurements & raw data
  • Methods, quality checks & results report
Advanced research

Advance

Scope advanced equipment, shared measurements, and any dedicated work.

Custom research scope
  • Specialist instrumentation plan
  • Expanded measurements & analysis
  • Milestone tracking & expert review

All projects require a custom quote and provider availability check. Nonprofits can request a budget-conscious scope.

START A PROJECT

Tell us what
you need.

Describe the data you need so we can assess a shared study and quote your portion. Creating a brief is free.

FLAME is in early development. A brief does not book a study or take payment.

Your research brief

01 / START HERE

Saved to your account. This is not a paid order or confirmed study.

Questions

Can I run a study at home?+

Individual access is for learning, data review, and planning. Human brain-stimulation experiments require an appropriate qualified setting and oversight.

Does sharing a study mean sharing my confidential work?+

No. Participants receive only the data covered by the agreed scope and access rights. Company-specific inputs and proprietary results are not automatically shared.

What does data validation include?+

The study scope defines calibration, controls, repeatability or other relevant checks, and acceptance criteria. You receive those checks and their limitations. A reviewed dataset or DTUSN comparison does not by itself prove clinical safety or effectiveness.

Are labs already available?+

Provider relationships, capabilities, availability, and approvals must be confirmed before a project is accepted.